Potential negative effect of testosterone on prostate has led to the development of selective androgen receptor modulators that activate tissue-selective androgenic signalling, SARMs (Selective Androgen Receptor Modulators), a class of compounds used to treat muscle wasting associated with cancer, acute and chronic illness, and age-related muscle loss.

LGD-4033 Ligandrol 5mg x 60Caps

64,99 €

54,99 €

Määrä

Potential negative effect of testosterone on prostate has led to the development of selective androgen receptor modulators that activate tissue-selective androgenic signalling, SARMs (Selective Androgen Receptor Modulators), a class of compounds used to treat muscle wasting associated with cancer, acute and chronic illness, and age-related muscle loss.

Ligandrol (LGD-4033) is a non-steroidal oral SARM which binds AR with high affinity (Ki of ~1 nM) and selectivity. It elicits therapeutic effect of testosterone with an improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action, and an oral route of administration.

In animal models this SARM demonstrates a robust selectivity for bone and muscle versus prostate and sebaceous glands, as well as anabolic and anti-resorptive activities in muscles and bones. Phase I clinical trial study showed Ligandrol to be safe, with a favourable pharacokinetic profile: the safety and tolerability have been established up to doses of 22mg; levels of haemoglobin, alanine aminotransferase, prostate-specific antigen, aspartate aminotransferase, and QT intervals are not altered significantly at any dose; the lean body mass is increased even during a short period without changes in prostate-specific antigen; it has a long elimination half-life as well as dose-proportional accumulation upon multiple dosing.

LGD-4033 administration can be associated with a dose-dependent suppression of total testosterone, SHBG (sex hormone-binding globulin), HDL (high density lipoprotein), cholesterol, and triglyceride levels.

Description:

Formula: 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile
Formula: C15H14F6N2
Molecular weight: 336.28
Molecular Structure:

Synonyms:

Ligandrol, SARMs, Selective Androgen Receptor Modulator, LGD-4033.

Physical Appearance:

White tablets.

Specificity:

LGD-4033 selectively binds androgen receptors in certain tissues.

Purity:

>99.9% (HPLC analyzed).

Stability:

Store at at 20 °C in dry place until the expiration date.

Source: Chemical Synthesis

Usage:

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

LGD-4033 Ligandrol 5mg x 60Caps

Description