What is 5 Amino 1MQ Peptide
5-AMINO-1MQ is a small molecule known for inhibiting the activity of NNMT, a cytosolic enzyme responsible for regulating cell energy balance and controlling fat tissue. Essentially, NNMT acts to slow down fat cell metabolism, making it more challenging for cells in the body to burn fat. Consequently, increased fat tissue can lead to the generation of more hormones and inflammatory signals, contributing to the development of various chronic diseases.
Furthermore, 5-AMINO-1MQ peptide has been found to increase nicotinamide adenine dinucleotide (NAD+), a key factor in cellular metabolism, thereby boosting metabolic rate.
Research conducted on mice has demonstrated a significant reduction in body mass (approximately 7%) over 10 days without any changes in food consumption when administered with 1MQ. Additionally, studies suggest that reducing NNMT activity may shrink fat cells and decrease the size of fat deposits.
Moreover, 5-AMINO-1MQ exhibits promising potential in treating a variety of diseases. Since NNMT has been implicated in various conditions such as osteoarthritis, cardiovascular disease, kidney disease, Parkinson's disease, and cancer, scientists believe that 5-AMINO-1MQ peptide could offer therapeutic benefits for these ailments.
In terms of weight loss, scientific studies have shown that higher NNMT expression is associated with obesity and type-2 diabetes. Researchers are currently developing 5-AMINO-1MQ drugs to target NNMT and induce specific reactions in white adipose tissue, which could lead to significant weight loss and aid in diabetes prevention.
Despite the need for further understanding regarding the underlying molecular mechanisms and their connection to NNMT activity, researchers believe that targeted inhibitors of NNMT, such as 5-AMINO-1MQ, could be highly beneficial in investigating therapeutic interventions for metabolic and chronic diseases.
Studies on mice with diet-induced obesity have demonstrated a substantial decrease in adipocyte size and volume, as well as reduced total cholesterol levels, when treated with 5-AMINO-1MQ. Neelakantan et al. (2018) found that mice given 1MQ displayed a 7% reduction in body mass over 10 days without any alterations in food consumption. Additionally, Neelakantan et al. (2019) demonstrated that inhibiting NNMT with 5-AMINO-1MQ increased muscle repair by activating stem cells, indicating its potential in improving muscle function and mobility, particularly in elderly individuals.
Furthermore, research suggests that 5-AMINO-1MQ may offer cognitive benefits by impacting NAD+ levels in the brain, potentially enhancing overall cognitive function. Although more clinical trials are needed, early results indicate promising cognitive benefits of 5-AMINO-1MQ.
In conclusion, 5-AMINO-1MQ holds promise as a therapeutic agent for various health conditions, including obesity, diabetes, neurodegenerative diseases, and muscle-related disorders. Further research and clinical trials are necessary to fully explore its potential benefits and ensure its safety and efficacy for human use.
References:
1. Neelakantan, H., Vance, V., Wetzel, M. D., Wang, H.-Y. L., McHardy, S. F., Finnerty, C. C., ... & Watowich, S. J. (2018). Selective and Membrane-Permeable Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Reverse High Fat Diet-Induced Obesity in Mice. Biochemical Pharmacology, 147, 141-152.
2. Neelakantan, H., Brightwell, C. R., Graber, T. G., Maroto, R., Wang, H.-Y. L., McHardy, S. F., ... & Watowich, S. J. (2019). Small Molecule Nicotinamide N-Methyltransferase Inhibitor Activates Senescent Muscle Stem Cells and Improves Regenerative Capacity of Aged Skeletal Muscle. Biochemical Pharmacology, 163, 481-492.